Order Systane Ultra

IT'S DOUBLE
OR NOTHING

SYSTANE® Ultra Hydration Lubricant Eye Drops Preservative-Free uses the power of HA + HP-guar to deliver effective dry eye relief and outstanding patient satisfaction1,2

MULTIDOSE,
PRESERVATIVE-FREE
DRY EYE SYMPTOM
RELIEF

Alcon's first exclusive
professional product

ORDER SYSTANE® ULTRA HYDRATION PRESERVATIVE-FREE NOW

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HA=hyaluronic acid

HYALURONIC ACID + HP-GUAR:
DOUBLE POLYMER ACTION FOR ADVANCED HYDRATION


HP-guar is a natural polysaccharide found in guar gum that helps artificial tears mimic the properties of natural tears.^1,3		When exposed to the pH of the tear film and ocular surface, HP-guar forms a protective viscoelastic gel matrix that supports corneal healing. HP-guar combined with HA creates a dual polymer formula that provides 2x better protection against dryness and 2x the lubricity of HA alone.^1,4

On its own, HP-guar demonstrates 2x greater symptom improvement in post-surgical patients vs. standard of care.5* See what happens when it combines with HA to create a dual polymer.

*Study design: Prospective, parallel, randomized, investigator-masked, single-center clinical study. Eligible patients were scheduled to undergo routine cataract removal and intraocular lens implantation. Patients were randomly assigned to either standard-of-care (n=20) or SYSTANE® ULTRA + standard-of-care (n=20) eye drops. The standard-of-care regimen consisted of moxifloxacin ophthalmic solution dosed QID for 1 week, and nepafenac and prednisolone ophthalmic solutions dosed QID for 1 week, then tapered down by 1 daily dose each week through 4 weeks. Patients were seen at 4 study visits: prior to surgery, and postoperative Days 1, 7, and 30. Change from baseline in OSDI was clinically significant in SYSTANE® ULTRA + standard-of-care group.5

SYSTANE® ULTRA HYDRATION:
HEAD-TO-HEAD VS. OTHER HA-CONTAINING DROPS

•	Greater moisture retention1,*
•	Better protection against dryness1,*

•	Repair effect: Significantly improved rate of corneal healing vs. other in-market HA-containing drops7,‡
•	Significantly improves ocular symptoms of dry eye, with >20 point improvement in OSDI score6,†
HA + HP-guar delivers both higher lubricity and higher viscosity than other leading HA-containing drops, reducing surface friction and staying on the eye longer1,*

* Compared to HA alone in an in vitro study. Human corneal epithelial cells were grown to confluence. Media were then removed and cells were incubated with test formulations for 30 minutes at 37°C. Test formulations were removed and cells were rinsed 5 times with media before desiccation at 37°C with 45% humidity for 30 minutes. Cell viability was assessed using an MTS assay.1
† Prospective, parallel, randomized, investigator-masked, single-center clinical study. Eligible patients were scheduled to undergo routine cataract removal and intraocular lens implantation. Patients were randomly assigned to either standard-of-care (n=20) or SYSTANE® ULTRA + standard-of-care (n=20) eye drops. The standard-of-care regimen consisted of moxifloxacin ophthalmic solution dosed QID for 1 week, and nepafenac and prednisolone ophthalmic solutions dosed QID for 1 week, then tapered down by 1 daily dose each week through 4 weeks. Patients were seen at 4 study visits: prior to surgery, and postoperative Days 1, 7, and 30. Change from baseline in OSDI was clinically significant in SYSTANE® ULTRA + standard-of-care group5
‡ Preclinical study evaluating the effect of 6 artificial tear products (OPTIVE FUSION®, Allergan Limited; VISMED®, TRB Chemedica International SA; Thealoz Duo®, Thea Pharmaceuticals Limited; Hyabak®, Thea Pharmaceuticals Limited; HYLO-COMOD®, URSAPHARM Arzneimittel GmbH; and Systane® HYDRATION, Alcon Laboratories Pty Ltd) on re-epithelialization of a corneal debridement wound following topical ocular administration in mice. Sixteen mice were randomized 1:1 to each treatment group (96 mice total). The epithelium of one cornea was debrided in each animal, and test solutions were administered every 2 hours after for a total of 4 administrations. To evaluate the number of re-epithelialized corneas (fluorescein negative) in each treatment group 24 hours after debridement, corneas were stained with fluorescein, imaged, and analyzed to calculate the total fluorescein-positive area. The difference in positive fluorescein pixels was statistically significant between Systane® HYDRATION vs OPTIVE FUSION® (p=0.0001), VISMED® (p=0.0001), Thealoz Duo® (p=0.0016), Hyabak® (p=0.0001), and HYLO-COMOD® (p=0.0369).7

DRY EYE PATIENTS HAVE AN OVERWHELMINGLY POSITIVE EXPERIENCE WITH SYSTANE^® ULTRA HYDRATION²

Help Enhance Your Dry Eye Patients’ Experience By
Recommending Systane® Ultra Hydration In Your Practice2


of patients had a positive experience with Systane® ULTRA HYDRATION (n=155)2	of eye care professionals said they ‘definitely will’ or ‘probably will’ recommend Systane® ULTRA HYDRATION for their patients (n=17)2	of patients said Systane® ULTRA HYDRATION was ‘better’ or ‘much better’ than their previous drops (n=120)2

Plus…
	•	87% of patients said they felt dry eye relief in less than 5 minutes (n=155)2
	•	85% of patients said they would probably or definitely recommend Systane® ULTRA HYDRATION (n=155)2
	•	87% of patients said they were likely to purchase Systane® ULTRA HYDRATION (n=155)2

Responses are based on a survey of Canadian dry eye patients (n=155) and eye care professionals (n=17). Survey was conducted between April 8, 2021 and September 8, 2021.

References:
1.	Rangarajan R, Kraybill B, Ogundele A, Ketelson H. Effects of a hyaluronic acid/hydroxypropyl guar artificial tearnsolution on protection, recovery, and lubricity in models of corneal epithelium. J Ocul Pharmacol Ther. 2015;31(8):491-497.
2.	Alcon Data on File. PEaCE Survey: Systane Hydration MDPF Canada. September 2021. Conducted by KS&R.
3.	Petricek I, et al. Hydroxypropyl-guar gellable lubricant eye drops for dry eye treatment. Expert Opin Pharmacother. 2008. 9(8): 1431-6.
4.	Srinivasan S, Manoj V. A Decade of Effective Dry Eye Disease Management with Systane Ultra (Polyethylene Glycol/Propylene Glycol with Hydroxypropyl Guar) Lubricant Eye Drops. Clin Ophthalmol. 2021;15:2421-2435.
5.	Davidson R, Schultz-Scott B. Efficacy Evaluation of SYSTANE® ULTRA in Patients With Dry Eye Undergoing Cataract Surgery. Poster presented at: 30th Congress of the European Society of Cataract and Refractive Surgeons; September 8-12, 2012; Milan, Italy.
6.	Mrukwa-Kominek E, et al. First clinical reports on the application of the modern dual-polymer formula in aqueous deficiency dry eye syndrome - Polish observations. Presented at the 20th European Society of Cataract and Refractive Surgery (ESCRS) Winter Meeting. Feb 26-28, 2016.
7.	Carlson E, Kao W, Ogundele A. Impact of Hyaluronic Acid-Containing Artificial Tear Products on Reepithelialization in an In Vivo Corneal Wound Model. J Ocul Pharmacol Ther. 2018;34(4):360-364.